The interface of nanotechnology and the human immune system

12 May 2017
Auditorium, Peter Doherty Institute, 792 Elizabeth Street, Melbourne

Seminar abstract

The interaction of nanomaterials with biological systems is conventionally restricted to cell line and rodent models. This thesis examined key physicochemical parameters that influence how novel nano- and micro-particles interact with the human immune system. Flow cytometry and confocal microscopy were employed to characterise the role of antibody-targeting, charge, surface chemistry and the plasma protein corona in various human blood models. Antibody-targeting enabled internalization of nanoparticles into non-phagocytic T cells, while both charge and surface chemistry demonstrated clear patterns of cell association and activation that may aid the rational design of future nanomedicines.

Details

Join Josh Glass from the Peter Doherty Institute for Infection and Immunity, when he delivers his PhD Completion Seminar. The seminar will commence at 3.15pm.