Isolating, capturing and releasing rare single cells for precision medicine

Project leader

Prof Justin Gooding (UNSW)

Big questions

How can we understand the heterogeneity in cell populations, and in particular rare cells such as circulating tumour cells?  This program aims to provide a new tool for biomedical researchers to capture rare cells and then be able to release individual cells of interest for further analysis such as genomic screening, cloning or single cell bioassays. Such a technology will have implications for both fundamental research in understanding cell heterogeneity and in precision medicine where therapeutic strategies can be designed for the heterogeneity in the cells of a given patient.

Rationale 

The ability to look at each rare cell individually will allow us to discern the pathological cells from the benign ones. By examining these pathological rare cells, we can fabricate new therapeutics that are more effective towards them.