Manipulating cell-biomaterial interactions to direct stem cell fate for regenerative medicine”
Free event ARC Centre of Excellence in Convergent Bio-Nano Science and Technology (CBNS) Seminar
Title: “Manipulating cell-biomaterial interactions to direct stem cell fate for regenerative medicine”
Speaker: Dr Jess Frith, Materials Science and Engineering, Monash University
Date: Friday, 13 November 2015, 11am-12pm
Venue: Lecture Theatre 5 (bldg. 401), Monash University, Parkville
Mesenchymal stem cells (MSCs) are attractive candidates for tissue engineering, as a result of their availability, immunosuppressive properties and ability to differentiate into multiple tissue types. When combined with tailored biomaterial systems, it is hoped that MSCs will be used to regenerate damaged tissues including bone, cartilage, tendon and intervertebral disc. However, a major challenge in realising this goal is the ability to fully direct MSCs to generate the desired tissue type and thus the considerable potential of these cells will remain untapped until we can efficiently direct their differentiation in these artificial microenvironments.
It is increasingly recognised that physical cues from the extracellular microenvironment have an important role to play in directing MSC fate. This presentation will outline the use of a number of cutting-edge biomaterial systems to elucidate the effects of specific extracellular cues upon MSC behaviour, showing that factors such as substrate viscoelasticity, ligand specificity and nanoscale ligand presentation all affect MSC fate. Current work is now focused on elucidating the role that microRNAs play in the regulation of these responses. Knowledge of these mechanisms has significant potential to be translated into improved biomaterials for tissue engineering applications.
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