The Centre’s research program is exemplified by the CBNS signature projects. In these interdisciplinary and collaborative research activities we aim to advance our fundamental understanding of the bio-nano interface, at a range of scales—cell, cell cluster or tumour, and organ level. This knowledge enables prediction, control and visualisation of the bio-nano interface resulting in improved vaccine delivery, increased drug efficacy, and enhanced imaging and diagnostics.
The CBNS signature projects have been developed to address significant, unanswered questions that cannot be solved by small groups over short periods of time with comparatively narrow expertise.
- A material scientist's guide to the cell - Prof Rob Parton and Dr Angus Johnston. By understanding the internalisation and trafficking of nanoparticles inside cells, we aim to optimise the therapeutic response to drugs.
- Developing predictive models of bio-nano interactions - Prof Stephen Kent with Prof Edmund Crampin. By studying the interactions of a range of nanoparticles in blood we aim to develop predictive models of nanoparticle properties.
- Measuring the 'magic bullet': quantifying active targeting - A/Prof Kris Thurecht. By targeting nanoparticles to cellular proteins to enhance drug accumulation in tumours we investigate whether therapeutic efficacy is increased. We seek to quantify the contribution that targeting ligands play in the accumulation and biodistribution of these nanoparticles.
- Isolating, capturing and releasing rare single cells for precision medicine - Prof Justin Gooding. By capturing rare migratory cancer cells we seek to understand the phenotype of these cells and the internalisation and trafficking of nanomedicines for therapeutic benefit.
- Nanoparticles in cancer drug delivery - Prof Maria Kavallaris. We aim to use our understanding of nanoparticle properties, specifically the characteristics related to targeting, to improve therapy development for aggressive cancers and micrometastatic disease.
- Bio-nano visualisation - Dr John McGhee. We are studying whether the use of immersive 3D virtual reality, generated using CBNS scientific data, improves the comprehension of the complex cellular and subcellular processes we study.
- Social dimensions: into the panoply of precision and personalisation - A/Prof Matthew Kearnes. By studying collaborative bio-nano research we are exploring how new social and healthcare practices evolve.
A bio-nano imaging signature project is being formulated and will build on the outcomes of the first phase signature projects.
Interdisciplinary and multi-nodal signature project teams have formed with the shared goal of addressing these challenges and increasing our understanding of the bio-nano interface.
We leverage these advances in fundamental bio-nano science to enable the development of novel and innovative technologies.