Understanding the internalisation and trafficking of nanoparticles in cells

Project co-leaders

Prof Rob Parton (UQ) & Dr Angus Johnston (Monash)

Big questions

Can we control the trafficking of nanoparticles inside cells to optimise the therapeutic response of drugs?


Effective drug delivery depends on delivering drugs to the sites in the cell where they are therapeutically active. The goal of this project is to gain a fundamental understanding of how nanoparticles are trafficked in cells. In particular, we will focus on understanding how nanoparticles and their cargo are internalised, trafficked in the endosomes and trafficked from the endosome into the cytoplasm (i.e. endosomal escape). These fundamental interactions are poorly understood and by understanding these interactions we aim to engineer the next generation of nanoparticles that can respond intelligently to the cellular environment.