Theme leader: Professor Stephen Kent, University of Melbourne
How nanoengineered structures interact with immune cells is poorly understood. Researchers across the CBNS have the wide range of expertise that permits us to finely tune nanoengineered structures to study their interaction with immune cells. This allows us to compare and contrast divergent nanoparticle systems to understand the most efficient mechanisms to deliver appropriate vaccine antigens to immune cells.
Through one of the Signature Projects we are using the computational biology methods to analyse resarch of the Vaccines theme to develop testable 'rules' of how nanoparticle physical properties (e.g. charge and size) effect interaction with human immune cells. In parallel, CBNS researchers are continuing to design and test improved vaccine concepts for testing.
CBNS Annual Reports provide details of the various activities within the Vaccines theme.
Image: Schematic illustration of the retention of PEG particles in the bloodstream (green), which indicates their low phagocytic cell (blue) association and extended circulation time.
ACS Nano 2015 9(1), 1571, DOI: 10.1021/nn5061578.